I'm not sure I understand what you mean, by "without the emulator", but I advise you to check that out :
https://github.com/Hoffa/nSDL/wiki/How-to-guide

AFAICT, there are some API differences between nSDL and PC SDL, so you'll have to handle them explicitly by yourself, in your program.

Actually it is multi-platform, except for the TI-Nspire-specific functions that are not part of standard SDL (which you can view here). That means you won't be able to use nSDL's font system to draw strings on your PC basically (it could be integrated into a custom PC SDL build without too much trouble however, as it's not just a bunch of separate files dependent on nothing but standard SDL). So just write your SDL games using 320x240 resolution and 16-bit color depth and you'll be fine (of course no audio support on TI-Nspire as you can imagine)

Thanks Hoffa! ^^
By the way, Is SDL_gfx compatible with nSDL?

* Eiyeron dreams about rotozoom

It isn't, haven't had the time to port it (this made me remember I have a half-assed port of SDL_image also somewhere). Actually I just checked the source code of SDL_gfx, and it's just a few files, so porting should be that difficult at all (with a bit of luck it won't require and code change at all). I for one have my exams currently so I won't have the time, but if you're up for the task go for it (I might however try in a few days if I find a few hours free).

EDIT: As far as I can remember, rotozoom is pretty damn slow even on a desktop PC. Maybe they've optimized it a bit since, but I'm not sure how well it'll perform.