These are good for small 2D games. I wouldn't recommend a scripting language for a large game. See how Minecraft is in Java (which is a JIT language, better than interpreted, in turn better than scripted) and yet it performs like crap.

Well, that's kinda true. But if you want 3D, go for a nice native language. Also some games require a lot of speed while not really complex/big.

No need to throw away all of that processing power though

Example of a waste of processing power:
var c;
t+=1;
for(xx=0;xx<room_width/8;xx+=1){
  for(yy=0;yy<room_height/8;yy+=1){
  draw_set_color(make_color_hsv(100*sin(point_distance(xx+15*sin(0.12*t),yy+4*cos(0.04*t),128,256)/10.72)+40*cos(0.2*yy)+5*t+sin(point_distance(xx, yy, (128 * sin(-t) + 128), (128 * cos(-t) + 128)) / 40.74),200,200));
    draw_rectangle(xx*8,yy*8,xx*8+8,yy*8+8,0);
  }
}


looks like js to me

I planned to port Illusiat or ROL games to RPG Maker in the past, but what held me back was the lack of non-copyrighted graphics. I just don't want such game to look exactly like most other RPG Maker games.

You can use any graphic that you want. The issue is that to make graphics yourselves, you need good pixel art skills. (at least I got ground tiles, though, but my tree ones are questionable quality IIRC, plus I lack large monsters)