Did you check the instruction manual to make sure every installation step were followed and that you meet the minimum requirements? For example, only the TI-84 Plus calculators that were manufactured from Summer 2004 to Winter 2007 will run TI-Boy SE, due to an hardware change made by Texas Instruments afterward.
Also make sure to give more details about what problem you have, such as error messages, crashes or even explosions that occured when you tried to run it.