Just like any computer, for a language to run an interpreter has to be made for it. There's nothing preventing other languages from running on it, except for lacking a port. Axe, in particular, would need modifications to accomodate the new OS structure, but most of the internal code it generates would be fine as-is.
Also, Forth is not as hard as z80, at least in my opinion. However, it's not exactly straightforward to look at.